A hybrid discrete-continuum model of immune responses to SARS-CoV-2 infection in the lung alveolar region, with a focus on interferon induced innate responseArticle Published on 2022-12-212022-11-15 Journal: Journal of theoretical biology [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] adaptive alveolar alveolar cells antibodies antibody antibody concentration baseline Cell cell death Cellular automaton COVID-19 develop diffusion domain Efficacy Future Gas exchange healthy human lung Immune cell immune protection immune response Immunity infected cell Infection initial Innate innate immune Innate immunity innate response Interaction interferon interferons lung alveolar maintain manuscript mechanism Model multiple mechanism outcome Pneumonia produced profiles progression Result RNA copy SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant simulations. Spread Strains submitted switching T cells the SARS-CoV-2 virus two-dimensional type I Viral load virion virions [DOI] 10.1016/j.jtbi.2022.111293 PMC 바로가기
Functional limitations 12 months after SARS-CoV-2 infection correlate with initial disease severity: An observational study of cardiopulmonary exercise capacity testing in COVID-19 convalescentsResearch article Published on 2022-10-012022-10-05 Journal: Respiratory medicine [Category] COVID19(2023년), SARS, 임상, 진단, [키워드] Cardiopulmonary changes Clinical course Clinical severity convalescent correlated COVID-19 diffusion capacity disease Dyspnea Efficiency exercise Exercise capacity extracorporeal membrane oxygenation Factor Gas exchange impairment independent initial intensive care treatment Invasive mechanical ventilation limitation lung morbidity muscular offered outcome oxygen uptake parameter parenchymal participant Participants Patient PCR positive performed predicted prospective observational study provide Pulmonary function test Quality of life questionnaire reduced reported Result resulting risk factor SARS-COV-2 infection survivor Testing Treatment ventilatory Ventilatory capacity was reduced [DOI] 10.1016/j.rmed.2022.106968 [Article Type] Research article
The impact of platelets on pulmonary microcirculation throughout COVID-19 and its persistent activating factorsArticle Published on 2022-09-282022-11-15 Journal: Frontiers in Immunology [Category] 치료제, [키워드] activate activating addition aggregation antiplatelet Blood coagulation factor complex convalescent COVID-19 COVID-19 patients disease severity disorders endothelial injury Factor Gas exchange hypercoagulability hypercoagulable hypercoagulable states Hypoxemia hypoxia immune cells impaired lung function impairment incidence Inflammation Inflammatory mediators inhibiting Intervention intrinsic involved Lung function manifestation marker microvesicle Microvesicles Mild Mortality Phosphatidylserine Platelet platelet activation Platelets promote PROTECT pulmonary permeability pulmonary vasculitis reactivity reducing resulting risk severe cases stages the disease therapy Thromboembolism thrombosis thrombosis. thrombotic event tissue Treatment vessel walls with COVID-19 [DOI] 10.3389/fimmu.2022.955654 PMC 바로가기
Effectiveness and safety of fibrinolytic therapy in critically ill patients with COVID-19 with ARDS: protocol for a prospective meta-analysisArticle Published on 2022-09-262022-11-16 Journal: BMJ Open [Category] meta-analysis, SARS, [키워드] acute respiratory distress anticoagulation ARDS bleeding disorder bleeding disorders & bleeding event clinical trial clinical trials Coagulopathies COVID-19 COVID-19 pandemic Critical care critical care. Critically ill patient Efficacy and safety eligibility criteria eligible Evidence fibrin deposit fibrinolytic FIVE Gas exchange identify IMPROVE include Intensive intensive & lung Meta-analysis microthrombi Mortality other organs outcome Oxygenation Patient patients patients with COVID-19 peer-reviewed performed PROSPERO protocol quantitative synthesis randomised controlled trial Registered Safety secondary outcome Standard of care syndrome therapy Trial ventilation/perfusion with COVID-19 [DOI] 10.1136/bmjopen-2022-063855 PMC 바로가기
ICU tracheotomies in patients with COVID-19: a lesson learned for future viral pandemicObservational Study Published on 2022-08-012022-10-04 Journal: European archives of oto-rhino-laryngology : offic [Category] Coronavirus, COVID19(2023년), SARS, 임상, [키워드] adverse event ARDS coronavirus SARS-CoV-2 COVID COVID patient COVID-19 COVID-19 patients Critically ill death demographic data feasible FiO2 Gas exchange ICU intubation IQR knowledge material mechanical ventilation mechanically ventilated patient median Open surgical tracheotomy outcome pandemic Patient PEEP Percutaneous Percutaneous tracheotomy Pneumonia Prognostic factor retrospective risk Safe significantly surgical survival rate tracheotomy Tracheotomy. ventilatory parameter Viral transmission [DOI] 10.1007/s00405-022-07360-4 PMC 바로가기 [Article Type] Observational Study
Immune and epithelial determinants of age-related risk and alveolar injury in fatal COVID-19치명적인 COVID-19에서 연령 관련 위험 및 폐포 손상의 면역 및 상피 결정인자Article Published on 2022-06-082022-09-12 Journal: JCI Insight [Category] MERS, 진단, [키워드] acute lung injury age aging alveolar alveolar injury Autopsy CD4+ CD8+ T cell Cell characterized contribute correlated COVID-19 cytotoxicity deficiency determinant Donor donors dysfunction early stage epithelial expressed fatal COVID-19 Gas exchange histopathological Immune cell increasing age individuals Infection lung lung damage Lung injury lymphocyte Macrophage Macrophage infiltration macrophages Older organ pathological stage performed pulmonary Pulmonary surfactants respiratory risk susceptibility T cell activation T cells T cells. underlie uninfected widespread [DOI] 10.1172/jci.insight.157608 PMC 바로가기 [Article Type] Article
Lung targeted liposomes for treating ARDSARDS 치료를 위한 폐 표적 리포솜Article Published on 2022-06-012022-09-11 Journal: Journal of controlled release : official journal o [Category] 치료제, [키워드] accumulate accumulation acute respiratory distress acute respiratory distress syndrome Administered administration alveolar approach ARDS BAL Bronchoalveolar lavage C57BL/6 characterized combined treatment COPD COVID-19 COVID-19 infections cysteine cytokine secretion distal DPPC drug Efficiency encapsulation endotracheal exhibited Gas exchange Hypoxemia IL-1β IL-6 impair infections Inflammation Inflammatory marker inflammatory markers intravenous intravenously lipid composition Lipid nanoparticles lipopolysaccharide Liposome lung lung damage Lung diseases lung disorders lung endothelial lung epithelial Lung inflammation Lungs Macrophage macrophages marker medication Methylprednisolone mice mortality rate mortality rates MPS mucolytic agent Mucus N-acetyl cysteine NAC nanoparticle Nanotechnology nitric oxide outcome Patient penetration provided pulmonary Pulmonary. reached reduce reducing Region respiratory respiratory distress Respiratory distress syndrome secretion steroid syndrome therapeutic therapeutic effect therapeutic efficacy TNFα Treatment Treatment outcome were assessed [DOI] 10.1016/j.jconrel.2022.03.028 PMC 바로가기 [Article Type] Article
Physiological Effects of Wearing N95 Respirator on Medical Staff During Prolong Work Hours in Covid-19 DepartmentsObservational Study Published on 2022-06-012022-10-05 Journal: Journal of occupational and environmental medicine [Category] 임상, [키워드] abnormality change changes in Department determine Effect Gas exchange Healthcare professional healthcare worker hour increase in medical staff not differ oxygen saturation performed physiological change plasma Prolonged prospective observational study provoke Respirator subject wearing work [DOI] 10.1097/JOM.0000000000002542 PMC 바로가기 [Article Type] Observational Study
Inhaled pulmonary vasodilators are not associated with improved gas exchange in mechanically ventilated patients with COVID-19: A retrospective cohort studyObservational Study Published on 2022-06-012022-10-05 Journal: Journal of critical care [Category] 임상, [키워드] 95% CI ARDS COVID-19 Effect Epoprostenol FIVE fixed Gas exchange index Inhaled Inhaled nitric oxide measure mechanically ventilated mechanically ventilated patient nasopharyngeal New York nine nitric oxide Observational cohort study Oxygenation Patient patients PCR positive Primary outcome respiratory Respiratory failure retrospective retrospective cohort study significantly treated university ventilatory Ventilatory ratio. was performed with COVID-19 [DOI] 10.1016/j.jcrc.2022.153990 PMC 바로가기 [Article Type] Observational Study
Effects of Wearing Face Masks on Exercise Capacity and Ventilatory Anaerobic Threshold in Healthy Subjects During the COVID-19 EpidemicRandomized Controlled Trial Published on 2022-05-302022-10-05 Journal: Medical science monitor : international medical jo [Category] 임상, [키워드] all subject anaerobic Analysis approach breath Capacity Cardiopulmonary changes in collected COVID-19 cross-over dead Effect exercise face Face mask Frequency Gas exchange healthy healthy volunteer independent influences on Mask men oxygen performed positive linear correlation Randomized significantly significantly higher subject threshold Ventilation ventilatory wearing wearing mask wearing masks women [DOI] 10.12659/MSM.936069 PMC 바로가기 [Article Type] Randomized Controlled Trial